Education: 

PhD: Biochemistry, University of Mysore, India, Dec-2016. 
Post-Doc: dept. of Dermatology, University of Colorado, Sept-2018 - 

Research Focus: 

Dr. Vaddi’s research focuses on the role of caspase-1 inflammasome in the mechanism of acquired resistance to melanoma immune therapy. His research helps to understand the autonomous activation of caspase-1 inflammasome in the malignant melanoma cell lines. His recent studies confirmed that pharmacological inhibition of caspase-1 inflammasome greatly benefits the anti-PD-1 therapy in malignant melanoma animal models. At present, his group is elucidating the significance of tumor intrinsic or extrinsic caspase-1 inflammasome and its substrate's role in the acquired resistance to melanoma immune therapy using specific animal models. Moreover, revealing the mechanism through which caspase-1 inflammasome’s substates regulate the generation of dysfunctional CD8 T cells and super-suppressive regulatory T cells in melanoma tumor-microenvironment. Dr. Vaddi is also involved in the project focusing on IL-37's role in the stability of regulatory T cells and the induction of tolerogenic dendritic cells.